Localization of a Conformational Epitope Common to Non-Native and Fibrillar Immunoglobulin Light Chains†
نویسندگان
چکیده
منابع مشابه
patterns and variations in native and non-native interlanguage pragmatic rating: effects of rater training, intercultural proficiency, and self-assessment
although there are studies on pragmatic assessment, to date, literature has been almost silent about native and non-native english raters’ criteria for the assessment of efl learners’ pragmatic performance. focusing on this topic, this study pursued four purposes. the first one was to find criteria for rating the speech acts of apology and refusal in l2 by native and non-native english teachers...
15 صفحه اولShark Immunoglobulin Light Chains
The humoral adaptive immune system of sharks is partly based on the same H2L2 heterodimeric antibody structure seen in all jawed vertebrates (reviewed in Flajnik 2002). The constituent vertebrate immunoglobulin (Ig) heavy (H) and light (L) chains provide obligate defense against pathogens and their toxins via neutralization, opsonization, and activation of the classical pathway of the complemen...
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Background: Immunoglobulins are a group of proteins that have important role in defense against microorganisms. Immunoglobulins consist of heavy and light chains. In human, immunoglobulin light chain comprises of two isotypes: Kappa (K) and lambda (λ) based on amino acid differences in carboxylic end of their constant region. Marked changes in the K to λ ratio can happen in monocl...
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15 صفحه اولLocalization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein.
Cast nephropathy is a severe complication of multiple myeloma. Binding of filtered monoclonal light chains (LC) with Tamm-Horsfall glycoprotein (THP) triggers heterotypic aggregation of these two proteins to form casts in the distal nephron of the kidney. To localize the LC binding site on THP, human THP was deglycosylated and underwent limited trypsin digestion in the presence or absence of a ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2007
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi0616605